abstract：BACKGROUND:Atrial fibrillation (AF) continues to be one of the most common cardiac problems, placing an expanding burden on the public health system. In several circumstances, AF can increase the risk of stroke and heart failure. Current pharmacologic treatment options are associated with the potential for significant ...

journal_title：American heart journal

authors： Pratt CM,Reiffel JA,Ellenbogen KA,Naccarelli GV,Kowey PR

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The long-term prognostic significance of early (<48 hours) ventricular fibrillation (VF) or sustained ventricular tachycardia (VT) in patients with an acute myocardial infarction remains controversial. Emerging data suggest that some of the benefit of renin-angiotensin-aldosterone system (RAAS) antagonism ma...

journal_title：American heart journal

authors： Askari AT,Shishehbor MH,Kaminski MA,Riley MJ,Hsu A,Lincoff AM,GUSTO-V Investigators.

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Left atrial (LA) volume is a prognostic index in chronic mitral regurgitation (MR). However, little is known about LA function in this setting. We hypothesized that LA dysfunction is related to pulmonary hypertension in chronic MR. METHODS:Seventy-one patients with organic chronic MR who underwent real-time...

journal_title：American heart journal

authors： Saraiva RM,Yamano T,Matsumura Y,Takasaki K,Toyono M,Agler DA,Greenberg N,Thomas JD,Shiota T

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Percutaneous pulmonary valve implantation (PPVI) has been introduced as therapy for right ventricular (RV) to pulmonary artery conduit dysfunction in patients with congenital heart disease. It has been shown that RV systolic function improved early after PPVI. The effects of PPVI on RV diastolic function and...

journal_title：American heart journal

authors： Romeih S,Kroft LJ,Bokenkamp R,Schalij MJ,Grotenhuis H,Hazekamp MG,Groenink M,de Roos A,Blom NA

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans. BACKGROUND:African-Americans reportedly have a lower risk of AF than whites despite their higher exposure to AF risk factors. However, precise estimates of AF incidence in Af...

journal_title：American heart journal

authors： Alonso A,Agarwal SK,Soliman EZ,Ambrose M,Chamberlain AM,Prineas RJ,Folsom AR

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:A strategy using coronary artery calcium (CAC) screening to refine coronary heart disease risk assessment in moderately high risk (MHR) subjects (10-year risk 10%-20%) has been suggested. The potential impact of this strategy is unknown. METHODS:Coronary artery calcium screening strategies focused on MHR su...

journal_title：American heart journal

authors： Patel MJ,de Lemos JA,McGuire DK,See R,Lindsey JB,Murphy SA,Grundy SM,Khera A

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Little is known about the role of diet in the development of venous thromboembolism (VTE). We explored the prospective relation of dietary patterns, food groups, and nutrients to incident VTE in older women. METHODS:In 1986, Iowa women aged 55 to 69 years completed a mailed survey, including a 127-item food...

journal_title：American heart journal

authors： Lutsey PL,Steffen LM,Virnig BA,Folsom AR

更新日期：2009-06-01 00:00:00

abstract：:The prevalence of heart failure (HF) is high and still on the rise. In 2004, an estimated 5.2 million adults in the United States carried the diagnosis of HF with a mortality rate of >19%. The incidence of HF is higher in individuals 65 years or older. As the US population grows older, the personal and economic costs ...

journal_title：American heart journal

authors： Gradman AH,Papademetriou V

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The study aimed to compare the short-term costs and long-term cost-effectiveness of 2 antithrombotics, fondaparinux and enoxaparin, for non-ST-elevation acute coronary syndrome in the United States. METHODS:It was based on a large randomized trial of 20,078 patients Fifth Organization to Assess Strategies i...

journal_title：American heart journal

authors： Sculpher MJ,Lozano-Ortega G,Sambrook J,Palmer S,Ormanidhi O,Bakhai A,Flather M,Steg PG,Mehta SR,Weintraub W

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Single nucleotide polymorphisms of vitamin K epoxide reductase complex subunit 1 (VKORC1) was reported to have association with arterial vascular disease. We investigated whether single nucleotide polymorphism of VKORC1 +2255 is associated with clinical outcomes among patients who underwent drug-eluting sten...

journal_title：American heart journal

authors： Suh JW,Baek SH,Park JS,Kang HJ,Chae IH,Choi DJ,Park HJ,Kim PJ,Seung KB,Kim HS

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Randomized trials have established efficacy of clopidogrel in various types of acute coronary syndromes (ACS). The objective of this study was to examine the temporal trends and patterns of early clopidogrel use (within the first 24 hours of hospitalization) across the spectrum of patients with ACS in Canada...

journal_title：American heart journal

authors： Rao RV,Goodman SG,Yan RT,Spencer FA,Fox KA,DeYoung JP,Rose B,Grondin FR,Gallo R,Gore JM,Yan AT,Canadian Global Registry of Acute Coronary Events (GRACE\/GRACE(2)) Investigators.

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:In China, low socioeconomic status (SES) may be a barrier for patients with coronary heart disease (CHD) to receive adequate treatment because of their inadequate access to health resources. This study aims to evaluate whether and to what extent SES is associated with the treatment of CHD patients. METHODS:...

journal_title：American heart journal

authors： Niu S,Zhao D,Zhu J,Liu J,Liu Q,Liu J,Wang W,Smith SC Jr,BRIG project.

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Although inflammation is a core element of atherogenesis and plasma levels of fibrinogen (FGB), homocysteine, and intercellular adhesion molecule-1 (ICAM-1) differ by race/ethnicity, little is known about the role of genetic polymorphisms in the FGB, methylenetetrahydrofolate reductase (MTHFR), and ICAM-1 ge...

journal_title：American heart journal

authors： Albert MA,Pare G,Morris A,Rose L,Buring J,Ridker PM,Zee RY

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is associated with increased risk of death, thromboembolic complications, and a lowered quality of life. Despite this burden, pharmacologic agents for prevention of AF in patients who achieved normal sinus rhythm are of limited utility, mostly because of serious and frequent side eff...

journal_title：American heart journal

authors： Macchia A,Varini S,Grancelli H,Nul D,Laffaye N,Ferrante D,Tognoni G,Doval HC,FORomegaARD investigators.

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Cohort studies have suggested little effect of coffee consumption on risk of acute myocardial infarction. The effect of coffee consumption on prognosis after myocardial infarction is uncertain. METHODS:In a population-based inception cohort study, we followed 1,369 patients hospitalized with a confirmed fir...

journal_title：American heart journal

authors： Mukamal KJ,Hallqvist J,Hammar N,Ljung R,Gémes K,Ahlbom A,Ahnve S,Janszky I

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Recent work has demonstrated a link between retinopathy, a marker of microvascular disease, and the development of heart failure, a finding particularly relevant in individuals with diabetes. Our objective was to assess the relationship between retinopathy and cardiac structure and function in a cohort of in...

journal_title：American heart journal

authors： Aguilar D,Hallman DM,Piller LB,Klein BE,Klein R,Devereux RB,Arnett DK,Gonzalez VH,Hanis CL

更新日期：2009-03-01 00:00:00

abstract：:Current evidence suggests that the pathogenesis of atrial fibrillation (AF) is multifactorial. The observation that AF, once present, alters the electrophysiologic properties of the atrial myocardium causing self-perpetuation of the arrhythmia raised the importance of electrical remodeling in its pathogenesis. Althoug...

journal_title：American heart journal

authors： Kourliouros A,Savelieva I,Kiotsekoglou A,Jahangiri M,Camm J

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Although the management of thoracic aortic aneurysms (TAAs) has improved significantly, patients presenting with aortic dissections, rupture, or other acute complications of TAAs continue to have high rates of morbidity and mortality. Accumulating data have indicated that many TAAs are due to underlying gene...

journal_title：American heart journal

authors： Eagle KA,GenTAC Consortium.

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Lipoprotein lipase (LPL) has a prominent role in the metabolism of triglycerides (TGs) and high-density lipoprotein cholesterol (HDL-C) and is a potential interesting target for the development of antiatherogenic treatment. To provide deeper insight into the role of natural variation in this gene, we investi...

journal_title：American heart journal

authors： Jensen MK,Rimm EB,Rader D,Schmidt EB,Sørensen TI,Vogel U,Overvad K,Mukamal KJ

更新日期：2009-02-01 00:00:00

abstract：:Guidelines published in 2001 recommended 1 regional adult congenital heart disease (ACHD) center per 3 to 10 million population. Our objective was to determine if published guidelines on the numbers of regional ACHD centers are sufficient to meet the needs of adults with congenital heart disease in the general populat...

journal_title：American heart journal

authors： Marelli AJ,Therrien J,Mackie AS,Ionescu-Ittu R,Pilote L

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to examine ethnic differences in depressive symptoms and antidepressant treatment in a cohort of patients undergoing diagnostic coronary angiography. BACKGROUND:Coronary heart disease (CHD) is the leading cause of mortality in the United States, with an excess of mortality in African...

journal_title：American heart journal

authors： Waldman SV,Blumenthal JA,Babyak MA,Sherwood A,Sketch M,Davidson J,Watkins LL

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Although prior studies have demonstrated disparities in the management and outcomes of women with acute coronary syndrome (ACS), there are limited large-scale contemporary data on gender differences in post-intervention outcomes in this population. METHODS:We analyzed patients according to 2 ACS categories,...

journal_title：American heart journal

authors： Akhter N,Milford-Beland S,Roe MT,Piana RN,Kao J,Shroff A

更新日期：2009-01-01 00:00:00

abstract：:Recently, the theory that hyperinflammation is the body's primary response to potent stimulus has been challenged. Indeed, a deregulation of the immune system could be the cause of multiple organ failure. So far, clinicians have focused on the last steps of the inflammatory cascade. However, little attention has been ...

journal_title：American heart journal

authors： Bodi V,Sanchis J,Nunez J,Mainar L,Minana G,Benet I,Solano C,Chorro FJ,Llacer A

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Although the safety and cost-effectiveness of same-day discharge after uncomplicated transradial percutaneous coronary intervention (TR-PCI) is well established in Europe and Asia, such data are not available for US patients. METHODS:All patients who underwent TR-PCI at our high-volume US medical center bet...

journal_title：American heart journal

authors： Jabara R,Gadesam R,Pendyala L,Chronos N,Crisco LV,King SB,Chen JP

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Selenium is a central determinant of antioxidative glutathione peroxidase 1 (GPx-1) expression and activity. The relevance of selenium supplementation on GPx-1 in coronary artery disease (CAD) needs to be established. We assessed the effect of selenium supplementation on GPx-1 in cell culture and on endothel...

journal_title：American heart journal

authors： Schnabel R,Lubos E,Messow CM,Sinning CR,Zeller T,Wild PS,Peetz D,Handy DE,Munzel T,Loscalzo J,Lackner KJ,Blankenberg S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Sirolimus-eluting stents (SES) prevent restenosis and repeat percutaneous coronary intervention (PCI), but safety data in unselected patients are limited, especially for intermediate-term follow-up. METHODS:All patients undergoing SES implantation at 4 Italian centers were enrolled into a dedicated database...

journal_title：American heart journal

authors： Sangiorgi G,Romagnoli E,Biondi-Zoccai G,Margheri M,Tamburino C,Barbagallo R,Falchetti E,Vittori G,Agostoni P,Cosgrave J,Colombo A,RECIPE (Real-world Eluting-stent Comparative Italian retrosPective Evaluation) Study Investigators.

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:The long-term prognostic significance of elevated cardiac markers in an undifferentiated patient population with chest pain is unknown. METHODS:Serum troponin I (cTnI), creatine kinase-MB (CK-MB), and myoglobin were measured at presentation in 951 consecutive patients evaluated in the emergency department f...

journal_title：American heart journal

authors： Jaffery Z,Nowak R,Khoury N,Tokarski G,Lanfear DE,Jacobsen G,McCord J

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:The CD40 receptor and its ligand (CD40L) are known to modulate both inflammation and thrombosis-2 processes important for the development and clinical expression of atherosclerosis. Circulating soluble CD40L (sCD40L) concentration predicts cardiovascular risk in selected patient samples. The purpose of this ...

journal_title：American heart journal

authors： Keaney JF Jr,Lipinska I,Larson MG,Dupuis J,Freedman JE,Hamburg NM,Massaro JM,Rong J,Sutherland P,Vita JA,Vasan RS,Benjamin EJ

更新日期：2008-11-01 00:00:00

abstract：:Patients with impaired glucose tolerance (IGT) have increased risk for developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Lifestyle modification and medication can prevent or delay progression to diabetes (PD), but whether such interventions also reduce the risk of CVD has not been rigorously...

journal_title：American heart journal

authors： Califf RM,Boolell M,Haffner SM,Bethel M,McMurray J,Duggal A,Holman RR,NAVIGATOR Study Group.

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:In 10,001 patients with stable coronary artery disease (CAD) enrolled in the Treating to New Targets (TNT) trial, 80 mg/d of atorvastatin (high-dose regimen) reduced the composite primary end point of death from CAD, nonfatal myocardial infarction, resuscitation from cardiac arrest, or stroke by 22% relative...

journal_title：American heart journal

authors： Mark DB,Knight JD,Cowper PA,Davidson-Ray L,Anstrom KJ

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Bleeding is associated with adverse outcome in acute coronary syndromes. However, the precise pathophysiologic mechanisms have not been elucidated. We sought to determine the relationship between bleeding and myocardial ischemia detected by concurrent continuous electrocardiogram (ECG) monitoring and their i...

journal_title：American heart journal

authors： Yan AT,Yan RT,Huynh T,DeYoung P,Weeks A,Fitchett DH,Langer A,Goodman SG,INTERACT Investigators.

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The optimal hydration strategy for prevention of contrast-induced acute kidney injury (AKI) remains unknown. The purpose of this meta-analysis is to compare the effectiveness of normal saline (NS) versus sodium bicarbonate hydration (NaHCO(3)) for prevention of contrast-induced AKI. METHODS:We performed a m...

journal_title：American heart journal

authors： Hogan SE,L'Allier P,Chetcuti S,Grossman PM,Nallamothu BK,Duvernoy C,Bates E,Moscucci M,Gurm HS

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Case fatality rates after acute myocardial infarction (MI) have decreased markedly over the last 3 decades. Some subgroups may have benefited more than others, but this hypothesis has not been evaluated in a large nationally representative cohort. Accordingly, we sought to assess long-term temporal trends in...

journal_title：American heart journal

authors： Wellenius GA,Mittleman MA

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers effectively reduce blood pressure in patients with renovascular disease (RVD); yet, randomized cardiovascular prevention trials of these drugs typically exclude individuals with this condition. PATIENTS AND METHODS:We studied the ass...

journal_title：American heart journal

authors： Hackam DG,Duong-Hua ML,Mamdani M,Li P,Tobe SW,Spence JD,Garg AX

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The contemporary magnitude and prognostic implications of complete heart block (CHB) in patients with acute myocardial infarction (AMI) are unknown. As part of a community-based study of patients hospitalized with AMI in the Worcester, MA, metropolitan area, changes over time in the incidence rates of CHB co...

journal_title：American heart journal

authors： Nguyen HL,Lessard D,Spencer FA,Yarzebski J,Zevallos JC,Gore JM,Goldberg RJ

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Controversy remains regarding whether gender differences exist in clinical management after exercise treadmill testing (ETT). METHODS:We studied 7,506 patients (49.8% women) without documented coronary heart disease referred for ETT from July 2001 to June 2004 in a community-based setting. We assessed the r...

journal_title：American heart journal

authors： Daugherty SL,Peterson PN,Magid DJ,Ho PM,Bondy J,Hokanson JE,Ross CA,Rumsfeld JS,Masoudi FA

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Women have been underrepresented in randomized trials of implantable cardioverter defibrillator (ICD) therapy, and limited data suggest that women may not benefit from prophylactic ICD implantation to the same extent as men. In the Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE)...

journal_title：American heart journal

authors： Albert CM,Quigg R,Saba S,Estes NA 3rd,Shaechter A,Subacius H,Howard A,Levine J,Kadish A,DEFINITE Investigators.

更新日期：2008-08-01 00:00:00

abstract：:Antiplatelet therapy is the current criterion standard for the treatment of patients undergoing percutaneous coronary intervention and patients who have acute coronary syndromes. Clopidogrel in combination with aspirin is the current standard of care for reducing cardiovascular events in these patients. However, patie...

journal_title：American heart journal

authors： Angiolillo DJ,Guzman LA,Bass TA

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) is one of the leading causes of morbidity and mortality among Americans. Despite increased interest in end-of-life care, the implications of do-not-resuscitate (DNR) orders in acutely ill patients with HF remain unclear. The goals of this observational study were to describe the use of DNR...

journal_title：American heart journal

authors： Chen JL,Sosnov J,Lessard D,Goldberg RJ

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Some pharmacist-managed anticoagulation services (PMAS) provide initial follow-up to patients on oral anticoagulant, who are transferred to their physician once they are stabilized. This may be as effective as and less expensive than long-term PMAS follow-up. METHODS:Once PMAS patients were stabilized and r...

journal_title：American heart journal

authors： Lalonde L,Martineau J,Blais N,Montigny M,Ginsberg J,Fournier M,Berbiche D,Vanier MC,Blais L,Perreault S,Rodrigues I

更新日期：2008-07-01 00:00:00